Open AccessTermination of Midtrimester Pregnancies Induced by Hypertonic Saline and Prostaglandin F 2α : 116 Consecutive Cases
Author(s) -
Bostofte E.,
Legarth J.
Publication year - 1981
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016348109155489
Subject(s) - medicine , hypertonic saline , abortion , prostaglandin , abortifacient , complication , obstetrics , oxytocin , pregnancy , saline , anesthesia , surgery , biology , genetics
In 116 patients, abortion was induced in midtrimester by intra‐amniotic administration of 20% hypertonic saline and 25 mg prostaglandin F 2α . Within 60 hours 113 aborted (success rate 97.4%). Of these 68.1% had aborted within 24 hours and 92.9% within 48 hours. Thirteen patients who had not aborted within 24 or 48 hours were treated with oxytocin drip. It is concluded that the combination studied is an effective abortifacient in midtrimester and that the injection‐abortion time is reasonable, the great majority aborting within 48 hours. No live fetuses were delivered, and the complication rate was acceptable.