Open AccessVON WILLEBRAND'S DISEASE AND PREGNANCY
Author(s) -
Punn R.,
Nyman D.,
Grönroos M.,
Wallén O.
Publication year - 1981
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016348109155470
Subject(s) - medicine , gestation , pregnancy , abortion , obstetrics , von willebrand disease , vaginal bleeding , bleeding time , gynecology , von willebrand factor , platelet , genetics , platelet aggregation , biology
. Seven new cases of pregnancy combined with von Willebrand's disease have been reported. Altogether the patients had 11 deliveries, and one abortion after 10 weeks' gestation. The diagnosis was based on the determination of the bleeding time, factor VIII coagulant activity (VIII C), factor VIII‐related antigen (VIII RAg) and the ristocetin co‐factor (VIII RCoF). Two of our 6 parturients showed profuse bleeding at delivery; in addition one patient showed bleeding after abortion at 10 weeks' gestation. Vaginal delivery is generally safe in patiens with von Willebrand's disease. There is a great risk of copious bleeding especially in connection with early abortion, when factor VIII levels are low.