Open AccessPROGESTERONE AND HUMAN CHORIONIC GONADOTROPHIN IN SERUM AND PREGNANDIOL IN URINE IN THREATENED ABORTION
Author(s) -
Hertz Jens B.,
Larsen Jöurgen Falck,
Arends Jöourgen,
Nielsen Jan
Publication year - 1980
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016348009160080
Subject(s) - threatened abortion , medicine , pregnancy , urine , abortion , pregnanediol , gynecology , hormone , obstetrics , pregnancy test , endocrine system , reference range , human chorionic gonadotropin , endocrinology , biology , genetics
. Progesterone and human chorionic gonadotrohin (HCG) in serum and pregnandiol in urine were measured in 64 patients admitted to hospital because of threatened abortion. Blood samples were taken and urine specimens collected at regular intervals during admission and after discharge during the rest of the pregnancy. A reference range was worked out for each hormone based on the hormone values obtained from the pregnancies proceeding to term. The predictive significance of values within and below the reference range was determined, for the initial sample and for serial samples. An association between hormone levels and outcome of pregnancy was observed but it is concluded that both single and serial determinations of progesterone and pregnandiol and serial determinations of HCG are unsatisfactory for the evaluation of threatened abortion. However, an initial progesterone value below the reference range and HCG values below 10000 mlU/ml between the 8th and 15th week of pregnancy was in every case always followed by spontaneous abortion. A hormonal test of fetoplacental origin is recommended for monitoring threatened abortion.