Open AccessRadioimmunoassay of hCG as an Early Diagnosis of Cerebral Metastases in Choriocarcinoma Patients
Author(s) -
Soma H.,
Takayama M.,
Tokoro K.,
Kikuchi T.,
Kikuchi K.,
Saegusa H.
Publication year - 1980
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016348009155426
Subject(s) - choriocarcinoma , radioimmunoassay , medicine , cerebrospinal fluid , chorioepithelioma , titer , endocrinology , antibody , immunology
To determine the early cerebral involvement of choriocarcinoma, the following studies were employed. By comparing hCG titers in measurements of serum and cerebrospinal fluid (CSF) hCG‐β through radioimmunoassay (RIA), serum/CSF ratios of titers were calculated in patients with normal pregnancies and in those with trophoblastic neoplasia. In normal pregnancies, the mean ratio of serum/CSF hCG was more than 45.5±6.0 (mean±SEM):1. In neoplasia without metastases to the brain, the ratio was more than 41.0:1. However, 2 patients with cerebral choriocarcinoma showed low ratios of 23.0:1 and 20.9:1, respectively. This suggests that determination of the β‐hCG concentration ratio of serum to CSF using RIA might give a more reliable evaluation for the early detection of choriocarcinoma metastasized to the brain.