Open AccessRadioimmunoassay of Serum Bile Acids in Normal Pregnancy and in Recurrent Cholestasis of Pregnancy
Author(s) -
Samuelson Kickan,
Thomassen Peter A.
Publication year - 1980
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016348009155420
Subject(s) - chenodeoxycholic acid , medicine , cholestasis of pregnancy , radioimmunoassay , pregnancy , cholestasis , bile acid , cholic acid , endocrinology , gestation , fetus , biology , genetics
Radioimmunoassay has been used to quantitate the conjugates of cholic and chenodeoxycholic acid in venous blood from women in different stages of normal pregnancy and in patients with recurrent intrahepatic cholestasis of pregnancy (RCP). The levels of cholic and chenodeoxycholic acid were shown to be within normal limits throughout uncomplicated pregnancy, and elevated in RCP. Because of RIAs simplicity and reliability, it is suggested that this method can be used to detect and follow the course of RCP and to assess the possible influence of treatment, e.g. diet.