Open AccessEffect of Dihydroergotamine on Coagulation Factors and Components of the Fibrinolytic System
Author(s) -
Svanberg Lars,
Bernstein Kurt,
Kullander Stig,
Åstedt Birger
Publication year - 1980
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016348009155405
Subject(s) - dihydroergotamine , medicine , coagulation , fibrinolysis , coagulation system , thromboelastography , pharmacology , migraine
Dihydroergotamine (DHE) was given to 20 gynecological patients, 0.5 mg i.m. preoperatively and again every twelfth hour for 7 days. No cases of thrombosis occurred as judged by the 125 I‐fibrinogen test. Increased concentrations, but within normal range, were found for fibrinogen, factor VIII activity and related antigen, plasminogen and antithrombin III and decreased concentration for α 2 ‐macroglobulin. The fibrinolytic activity of the wall of a superficial hand vein was not suppressed, which otherwise occurs postoperatively. Together with the increased concentration of antithrombin III this might explain the potentiating effect of DHE on prophylactic treatment with low‐dose heparin.