Open AccessGranulosa‐cell and theca‐cell tumors: The clinical picture and long‐term outcome for the radiumhemmet series
Author(s) -
Björkholm Elisabet,
Pettersson Folke
Publication year - 1980
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016348009154094
Subject(s) - medicine , menarche , granulosa cell , population , radiation therapy , ovary , gynecology , environmental health
Over the period 1923‐72 a total of 305 patients with granulosa‐cell, theca‐cell tumor and mixed tumor were seen at Radiumhemmet. The commonest symptom was abnormal uterine bleeding. Twenty‐three per cent of married women were nulliparous. The menarche seems to have occurred earlier in this group than in the general population. Eight of the granulosa‐cell tumor group gave birth to 12 children after treatment for the tumor. Nineteen women with granulosa‐cell tumor and 4 with thecoma had received radiotherapy earlier in life for benign lesions. The risk of endometrial cancer was approximately 10 times greater for the women with granulosa‐ or theca‐cell tumor than for the general population. Two hundred and fifty‐two patients were given both surgical treatment and radiotherapy. Fifty‐three received only surgery (37 granulosa‐cell and 16 theca‐cell tumors). None of the thecoma patients but 21 per cent of those with granulosa‐cell tumor died from their disease. The 5‐year survival for the latter group, all stages, was 85 per cent.