Open AccessNAPROXEN AND INDOMETHACIN IN THE TREATMENT OF PRIMARY DYSMENORRHEA
Author(s) -
Kajanoja Pauli,
Vesanto Tuulikki
Publication year - 1979
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016347909157797
Subject(s) - naproxen , medicine , side effect (computer science) , indometacin , anesthesia , symptomatic treatment , disease , cyclooxygenase , prostaglandin endoperoxide synthase , biochemistry , chemistry , enzyme , alternative medicine , pathology , computer science , programming language
. The efficacy of naproxen and indomethacin in the treatment of dysmenorrhea was compared in a double‐blind, cross‐over study. Both drugs were given to 24 female undergraduates with severe primary dysmenorrhea in four consecutive cycles in a randomized schedule. Both drugs were equally effective. Good or moderate overall relief was achieved in 73% of 48 cycles treated with indomethacin and in 61% of the 48 cycles treated with naproxen. The difference was not statistically significant. Gastrointestinal side‐effects occurred in 5 and 7 patients during naproxen and indomethacin treatment respectively. Central nervous system side‐effects, dizziness, headache, tiredness, were more common with indomethacin than with naproxen ( p <0.02). The most important and frequent of these side‐effects, dizziness, was complained of by six patients in association with indomethacin but by none with naproxen ( p <0.05). Only one patient discontinued the treatment because of side‐effects.