Open AccessTREATMENT OF POST‐MENOPAUSAL HYPERCHOLEROLAEMIA WITH ESTRADIOL
Author(s) -
Tikkanen M. J.,
Kuusi T.,
Vartiainen E.,
Nikkilä E. A.
Publication year - 1979
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016347909157234
Subject(s) - medicine , endocrinology , lipoprotein lipase , triglyceride , estradiol valerate , cholesterol , very low density lipoprotein , climacteric , lipoprotein , menopause , high density lipoprotein , estrogen , adipose tissue
Abstract. Replacement therapy with estradiol valerate in 29 post‐menopausal women reduced low‐density lipoprotein (LDL) cholesterol concentrations by 22% and increased high‐density lipoprotein (HDL) cholesterol by 21% after 12 months. Apart from a 67% increase of HDL‐triglyceride estradiol had only a slight effect on the levels of lipoprotein triglycerides. Post‐heparin plasma lipoprotein lipase (LPL) activity was significantly decreased in subjects with normal pre‐treatment very‐low‐density lipoprotein (VLDL) triglyceride levels, and hepatic lipase (HL) activity was significantly decreased in the group as a whole. It is suggested that estradiol replacement therapy should be considered in climacteric women with high LDL‐cholesterol or low HDL‐cholesterol levels, or both.