Open AccessASPECTS ON RIPENING OF THE CERVIX AND INDUCTION OF LABOR BY INTRACERVICAL APPLICATION OF PGE 2 IN VISCOUS GEL
Author(s) -
Ulmsten Ulf
Publication year - 1979
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016347909156814
Subject(s) - cervix , myometrium , ripening , prostaglandin , uterine cervix , uterus , prostaglandin e , prostaglandin e2 , induction of labor , chemistry , gynecology , andrology , medicine , endocrinology , pregnancy , biology , food science , carcinoma , cancer , genetics
. In this survey the effect of intracervically applied prostaglandin E 2 (PGE 2 ) on the pregnant uterus is outlined. It is concluded that PGE 2 decreases cervical resistance and stimulates the myometrium to contract. In small doses (0.25 mg and 0.5 mg) PGE 2 produces a rapid and prominent ripening of the cervix without systemic side effects and independent of prominent uterine contractions. Prostaglandin E 2 applied intracervically in viscous gel seems to be superior to previously used methods for treatment of patients with an unfavorable cervical state.