Open AccessBROMOCRIPTINE TREATMENT OF THE PREMENSTRUAL SYNDROME
Author(s) -
Kullander Stig,
Svanberg Lars
Publication year - 1979
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016347909154599
Subject(s) - bromocriptine , luteal phase , prolactin , medicine , endocrinology , basal (medicine) , serum concentration , premenstrual tension , hormone , menstrual cycle , insulin
. Bromocriptine, 2.5 mg twice a day was tested for its effect on premenstrual tension in a random double‐blind cross‐over trial. 1. The compound tended to lessen the symptoms, especially mastodynia. 2. Serum prolactin levels around the upper limit of the normal range were significantly lowered. Patients with the highest starting prolactin levels had the most severe symptoms and in these patients the fall in the levels was greatest. 3. Serum FSH and LH levels were significantly reciprocally influenced compared with serum prolactin. Serum estradiol‐17‐beta and progesterone did not change during treatment. 4. The bromocriptine‐treated cycles were all ovulatory according to basal temperature levels. The luteal phase was prolonged when serum FSH was raised.