
AMNIOTIC FLUID PHOSPHATIDYLINOSITOL AND PHOSPHATIDYLGLYCEROL
Author(s) -
Skjaeraasen Julie,
StrayPedersen S.
Publication year - 1979
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016347909154062
Subject(s) - amniotic fluid , medicine , phosphatidylglycerol , respiratory distress , lecithin , obstetrics , gestation , preeclampsia , pregnancy , andrology , phosphatidylinositol , sphingomyelin , gynecology , phospholipid , fetus , cholesterol , surgery , phosphatidylcholine , biology , chemistry , chromatography , biochemistry , genetics , kinase , membrane
. 139 samples of amniotic fluid from diabetic women collected during 34‐39 weeks of pregnancy showed higher levels of lecithin, phosphatidylinositol (PI) and phosphatidylglycerol (PG) indicating an accelerated surfactant synthesis as compared to that observed in normal pregnancies (13). In ten infants with respiratory distress syndrome (RDS) delivered from diabetic mothers the lecithin/sphingomyelin (L/S), PI/S and PG/S ratios were generally low. Only four samples showed definitely immature L/S ratios, whereas the amniotic fluid content of PG in all samples was unmeasurable or low. In 56 samples of amniotic fluid collected during the third trimester from preeclamptic pregnancies PI/S and PG/S ratios after 36‐37 weeks were comparable with those of normal pregnancies. In 11 neonates with subsequent RDS the L/S ratios were immature, and PG was critically low or lacking in the majority of the samples. No convincing association between the PI content and development of RDS could be observed in any of the groups.