Open AccessThe Influence of Locally Administered Prostaglandin E 2 and F 2α on Uterine Motility in the Intact Non‐Pregnant Human Uterus
Author(s) -
Martin J. N.,
Bygdeman M.,
Eneroth P.
Publication year - 1978
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016347809155894
Subject(s) - prostaglandin f2alpha , uterus , ovulation , endocrinology , estrogen , medicine , menstrual cycle , prostaglandin , prostaglandins f , motility , prostaglandin e2 , prostaglandin e , luteal phase , microgram , follicular phase , biology , hormone , in vitro , genetics , biochemistry
. Clinical studies on the effect of locally administered prostaglandin E 2 and F 2 α on the sensitivity and reactivity of the non‐pregnant human uterus were performed in 16 volunteers. With the use of the flaccid microballoon technique, uterine recordings were made at frequent intervals throughout the menstrual cycle. As little as 0.25 μg PGE 2 or 1.0 μg PGFM 2 α effected an increase in uterine motility during most of the proliferative and secretory phases of the menstrual cycle. However, a marked decrease in sensitivity and suppression of reactivity to either prostaglandin compound was observed around ovulation. Moreover, an inhibition of uterine contractility in response to PGE 2 but not to PGF 2 α was noted during active menstrual bleeding. Circulating levels of estrogen could be correlated generally with these uterine responses. Endogenous prostaglandins normally occur in the secretory endometrium in levels compatible with the amount of exogenously administered prostaglandins which elicited increased, decreased, or unchanged uterine activity in this study. These findings suggest that local prostaglandin E 2 and F 2 α in concert with variable levels of circulating estrogen, may play important roles in the cyclic regulation of uterine motility during the menstrual cycle.