Open AccessOn receptors for estrogens (e 2 ) and androgens (dht) in human endometrial carcinoma and ovarian tumours
Author(s) -
Friberg L. G.,
Kullander S.,
Persijn J. P.,
Korsten C. B.
Publication year - 1978
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016347809154895
Subject(s) - receptor , medicine , estrogen receptor , endocrinology , carcinoma , estrogen , epithelioma , cancer research , biology , cancer , breast cancer
. Some human endometrial carcinomas contain receptors for estrogen (E 2 ) and dihydrotestosteron (DHT). Analysis of 50 primary endometrial carcinomas by agar gel electrophoresis revealed a varying receptor pattern, absence of both receptors, sole presence of E 2 ‐ or DHT‐receptor, or presence of both. Highly differentiated tumours often had receptors of both types (7/18) and poorly differentiated tumours most often lacked them (1/10). Primary tumours with metastases (Stages III‐IV) seldom had combined receptors, only in 2 cases out of 9. Growth of the tumour down in the cervical canal (Stage II) implied absence of combined receptors in all of the 13 cases studied. In 8 different ovarian tumours, presence of either E 2 ‐ or DHT‐receptors was found in 6. The findings are discussed in relation to hormonal treatment of the disease.