Open AccessIntrauterine injection of vitamin k before the delivery during anticoagulant therapy of the mother
Author(s) -
Larsen Jørgen Falck,
Jacobsen Bo,
Holm Hans Henrik,
Pedersen Jan Fog,
Mantoni Margit
Publication year - 1978
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016347809154887
Subject(s) - medicine , in utero , coagulation , vitamin , vitamin k , factor ix , factor x , obstetrics , vitamin k deficiency , gestation , risk factor , factor vii , pediatrics , pregnancy , fetus , thrombin , genetics , platelet , biology
. The coagulation factors PP% (Factors II+IV), factor IX and factor X were determinated in infants born by mothers receiving anticoagulants. The factors were very low when the mothers did not receive vitamin K before the delivery. No significant improvement in the factors was observed after an intravenous or intraamniotic injection of vitamin K two to four days before the delivery. Vitamin K was injected intramuscularly into four foetuses in utero using an ultrasonic multitransducer scanner. Three of these infants had normal coagulation factors at birth. In the fourth case the factor X was normal and factor IX was significantly better than in the infants of the other groups. The injection had no harmful effects to the infants.