Open AccessComparison of extra‐amniotic instillation of rivanol and pgf 2α either separately or in combination followed by oxytocin for second trimester abortion
Author(s) -
Ölund Anders,
Larsson Bertil
Publication year - 1978
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016347809154027
Subject(s) - medicine , oxytocin , abortion , pregnancy , misoprostol , products of conception , obstetrics , amniotic fluid , anesthesia , fetus , genetics , biology
. Second trimester abortion was induced in 92 women by extra‐amniotic instillation of Rivanol and/or PGF 2α followed by intravenous oxytocin after 24 hours. All instillations were made via a catheter with a balloon filled with 30 ml and left in place until abortion, but never for more than 24 hours. Induction was started by Rivanol alone (n=23), PGF 2α alone (n=23), Rivanol combined with PGF 2α (n=23), or Rivanol combined with half dose PGF 2α (n = 23) and the patients were allotted to the different groups in a random manner. The Rivanol solution was instilled as a single dose but PGF 2α was instilled every 2nd hour for 24 hours. The mean induction‐abortion time was similar in all 4 groups but a number of patients given PGF 2α alone or in combination with Rivanol aborted earlier than patients induced by Rivanol alone, during the period before intravenous oxytocin was administered. Gastrointestinal side effects were equally common after Rivanol as after PGF 2α . With the methods and doses used in the present investigation PGF 2α alone or combined with Rivanol with subsequent oxytocin had no over‐all advantage over Rivanol.