Open AccessEffects of terbutaline on the pressure volume relationship in fetal rabbit lung
Author(s) -
Bergman B.,
Hedner T.,
Lundborg P.
Publication year - 1978
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016347809154025
Subject(s) - terbutaline , medicine , transpulmonary pressure , gestation , saline , lung , fetus , anesthesia , lung volumes , endocrinology , pregnancy , asthma , biology , genetics
. The pressure‐volume relationship in preterm rabbit lung was studied at 28 days of gestation, Injection of 0.1 mg terbutaline, a selective β 2 ‐receptor stimulating drug, significantly increased the volume of air at equivalent low transpulmonary pressures, compared to a saline treated group and an untreated group. These findings indicate an increased pulmonary distensibility of the fetal rabbit lung after terbutaline administration. The mechanism of action is discussed and surfactant mediated effects are suggested to be the probable explanation.