Open AccessStilbestrol Administration in the Puerperium and its Effect on the Prolactin Excretion of Non‐Lactating Patients
Author(s) -
David Am,
Romem Izhak,
Lunenfeld Bruno,
Kaufman Miriam,
Serr David M.
Publication year - 1977
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016347709162122
Subject(s) - stilbestrol , medicine , prolactin , lactation , placebo , radioimmunoassay , endocrinology , diethylstilbestrol , breastfeeding , hormone , physiology , pregnancy , obstetrics , pediatrics , alternative medicine , pathology , biology , genetics
. The relationship between stilbestrol treatment and placebo treatment was studied in 2 groups of non‐nursing patients. Plasma prolactin levels were evaluated in these 2 groups on day 1, 3 and 7 of the treatment, by a radioimmunoassay technique with the double antibody method using Serono hPRL kit. Our results show that prolactin values increased significantly in the stilbestrol‐group and decreased in the placebo group. It seems that the main reason for “the drying up of milk” is the lack of stimulation of the nipples, which after a relatively constant time of 5–10 days will lead to decreased prolactin levels. Stilbestrol treatment is not effective in “drying up” the milk more rapidly in patients who do not want to nurse. When patients have symptoms a combination of analgesia and breast support usually brings relief within 24 to 48 hours.