Open AccessEvaluation of Fetal Maturity by Amniotic Fluid Creatinine Concentrations and Lecithin/Sphingomyelin Ratio
Author(s) -
Skjæraasen J.,
Maltau J. M.
Publication year - 1977
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016347709162117
Subject(s) - amniotic fluid , medicine , creatinine , lecithin , gestation , fetus , sphingomyelin , endocrinology , pregnancy , andrology , chromatography , chemistry , biology , cholesterol , genetics
. In a material of 144 samples of amniotic fluid from the last trimester, creatinine concentration, lecithin/sphingomyelin (L/S) ratio and their correlation, have been examined. Amniotic fluid creatinine concentration (a.f.c.) increased gradually through the last trimester up to 39 weeks (273–279 days p.m.) with median values of 2 mg/100 ml at 37 weeks and 2.5 mg/100 ml at 39 weeks gestation. The great range makes a.f.c. of doubtful value in assessment of gestional age in individual samples. The correlation between a.f.c. and L/S ratio was highly significant (Kendall's T=0.56). Even so lung maturity cannot be predicted from a.f.c. A low L/S ratio with a.f.c. ≥2 mg/100 ml was found in 8–9%, while a.f.c. 1.1–1.9 mg/100 ml was combined with L/S ratios ≥2 in a great number of cases. A.f.c. <1.1 mg/100 ml was invariably correlated with low L/S ratios.