Open AccessPHARMACOKINETIC AND PHARMACODYNAMIC STUDIES ON OESTRADIOL VALERIANATE ADMINISTERED ORALLY TO POSTMENOPAUSAL WOMEN
Author(s) -
Englund D. E.,
Johansson E. D. B.
Publication year - 1977
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016347709156337
Subject(s) - medicine , pharmacokinetics , radioimmunoassay , pharmacodynamics , plasma concentration , norgestrel , postmenopausal women , endocrinology , levonorgestrel , menopause , plasma levels , population , research methodology , family planning , environmental health
. Peripheral plasma from four postmenopausal women was analysed for oestrone (E 1 ) and oestradiol (E 2 ) during 48 hours after oral intake of a single tablet of 2 mg Progynon ® (oestradiol valerianate). Plasma levels of E 1 , E 2 and d‐norgestrel were analysed daily in five postmenopausal women during treatment with tablet Cyclabil ® (oestradiol valerianate in a biphasic preparation with dl‐norgestrel) in 21 days. Radioimmunoassay (RIA) was utilized for the quantifications. Pretreatment plasma levels of E 1 were about 20 pg/ml and E 2 about 12 pg/ml. It is concluded that oestradiol valerianate is rapidly absorbed from the gastrointestinal tract and converted to E 1 . This is reflected by plasma levels of E 1 considerably higher than those of E 2 . The E 2 levels found were in the range of those in ovulatory women, while the oestrone levels were higher.