Open AccessEFFECT OF ALKOXYGLYCEROLS ON THE FREQUENCY OF INJURIES FOLLOWING RADIATION THERAPY FOR CARCINOMA OF THE UTERINE CERVIX
Author(s) -
Brohult Astrid,
Brohult Johan,
Brohult Sven,
Joelsson Ingemar
Publication year - 1977
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016347709155008
Subject(s) - medicine , radiation therapy , incidence (geometry) , cervix , radiation injury , surgery , carcinoma , cancer , physics , optics
. The incidence of injuries following intracavitary and external radiation therapy is markedly decreased in all stages of the disease by the administration of alkoxyglycerols. Complex injuries (due to radiation injury and tumour growth in combination) were reduced to about 1/3 in a group receiving alkoxyglycerols prophylactically, i.e. before, during and after radiation treatment, when compared with a control group. Using non‐prophylactic administration of alkoxyglycerols, i.e. during and after radiation treatment, no effect was observed on complex injuries, while—as for the prophylactic group—the injuries due to radiation only, were significantly decreased. The use of so called “increased amount” of radium in the intracavitary irradiator was followed by an unexpectedly high incidence of radiation injuries, which was considerably reduced, however, by alkoxyglycerols, especially when administered prophylactically.