Open AccessPhospholipids and Creatinine in Amniotic Fluid in Relation to Gestational Age
Author(s) -
Löfstrand Tord,
Fex Göran,
Holmberg NilsGunnar
Publication year - 1976
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016347609156803
Subject(s) - medicine , amniotic fluid , creatinine , obstetrics , gestational age , gestation , gynecology , pregnancy , fetus , biology , genetics
. 176 samples of amniotic fluid were obtained by abdominal amniocentesis from 69 women with complicated pregnancies (toxemia, diabetes mellitus or rhesus isoimmunization) in the 27th–43rd week of pregnancy. The concentration of creatinine (172 cases), the ratio of lecithin/sphingomyelin (L/S‐ratio, 155 cases) and phospholipid phosphorus (155 cases) were determined and related to gestational age. The results were compared with normal pregnancy. The mean level of creatinine in toxemia was significantly higher from the 32nd week till term ( p >0.05) and the L/S‐ratio was significantly higher ( p >0.05) in the 34th–35th week compared with normal pregnancy. Creatinine concentration was significantly elevated in diabetic pregnancy in the 36th–37th week ( p >0.05). Creatinine concentration tended to be low in Rh‐isoimmunization. A creatinine concentration ≤1.8 mg% and a L/S‐ratio ≤2.25 always corresponded to a gestational age ≤35th week. To get increased precision in estimating gestational age in complicated as well as in normal pregnancy the determination of both creatinine concentration and L/S‐ratio in amniotic fluid is recommended.