Open AccessThe Value of Amniotic Fluid Diamine Oxidase Estimations in the Management of Severe Rhesus Iso‐Immunization
Author(s) -
Ward Humphry,
Whyley G. A.,
Millar M. D.
Publication year - 1976
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016347609156786
Subject(s) - medicine , amniotic fluid , diamine oxidase , obstetrics , immunization , andrology , immunology , pregnancy , enzyme , antibody , fetus , biochemistry , genetics , chemistry , biology
. Serial estimations of the enzyme, diamine oxidase (D.A.O.) in liquor amnii were made in 82 rhesus sensitised women. Normal levels were found in severe disease with a favourable fetal outcome, but abnormal levels were found in 50% of the pregnancies in which severe disease was associated with fetal death. In addition, when liquor bilirubin levels predicted moderate‐severe disease, D.A.O. levels were abnormal in 75% of the pregnancies in which the fetus succumbed. Abnormally low D.A.O. levels in amniotic fluid were frequently associated with the subsequent development of disseminated intra‐vascular coagulation in the infant. Serial estimations of D.A.O. in amniotic fluid could be a helpful adjunct to serial liquor bilirubin estimations in the management of severe rhesus iso‐immunisation.