Open AccessANALYSIS OF A MULTICENTRE TRIAL OF A NEW LOW‐DOSE ORAL CONTRACEPTIVE IN GREAT BRITAIN
Author(s) -
Bye P. G. T.
Publication year - 1976
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016347609156450
Subject(s) - medicine , pill , breakthrough bleeding , pregnancy , obstetrics , family planning , gynecology , norgestrel , research methodology , population , genetics , environmental health , biology , pharmacology
. An oral contraceptive containing D‐norgestrel 150 μg. and ethinol oestradiol 30 μg. (Neovletta ® ) was tested in 682 British women during more than 6,000 cycles. The pregnancy rate was 0.2 per 100 womanyears with the exclusion of pregnancies that followed admitted errors of tablet‐taking, and 0.8 per 100 woman‐years when they were included. 92.2 per cent of cycles were within 28 ± 3 days. Withdrawal‐bleeding was missed in 3.3 per cent of cycles. Spotting occurred in 9.3 per cent of cycles and breakthrough bleeding in 5.8 per cent. Total bleeding averaged 4.71 days per cycle. Concurrent symptoms likely to be attributable to the pill were few and only 10.3 per cent of subjects withdrew because of them. It can be concluded that this formulation is extremely well tolerated and highly effective.