Open AccessThe Effect of Norethindrone and Some Other Synthetic Gestagens Upon the Peripheral Plasma Levels of Progesterone and Estradiol During Early, Human Pregnancy
Author(s) -
Nygren KarlGösta,
Johansson Elof D. B.
Publication year - 1975
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016347509158667
Subject(s) - medicine , norgestrel , pregnancy , chlormadinone acetate , radioimmunoassay , endocrinology , hormone , genitourinary system , population , research methodology , family planning , biology , environmental health , genetics
. Synthetic gestagens were given orally (norethindrone, d‐norgestrel, chlormadinone acetate) or intramuscularly (17α‐hydroxyprogesterone caproate) during 25 early, human pregnancies. The peripheral plasma levels of progesterone and estradiol were determined before, during and after the treatment. Norethindrone was most extensively used and in those women who received this gestagen the peripheral plasma levels of norethindrone were estimated by radioimmunoassay. No consistent effect upon the levels of progesterone or estradiol was observed. In 23 women no vaginal bleeding and no abortion occurred within about a week after the treatment. The pregnancies were terminated surgically. Histological examination of specimens from these abortions revealed no differences on comparison with 10 non‐treated controls. Two women aborted after the treatment, but judging from the hormonal levels these pregnancies were abnormal and would probably have aborted regardless of the treatment.