Open AccessEnzymatic Studies of Glycogen Metabolism in Nonmalignant and Malignant Biopsies from the Human Uterine Cervix
Author(s) -
Pedersen S. Nødskov
Publication year - 1975
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016347509157107
Subject(s) - medicine , glycogen , enzyme , uterine cervix , cervix , metabolism , biopsy , gynecology , pathology , biochemistry , carcinoma , cancer , biology
. The glycogen metabolism of the human uterine cervix has been investigated in tissue specimens from 147 women with gynaecological diseases: 64 with cervical carcinomas, 6 with carcinoma in situ and 77 with nonmalignant cervical diseases. The glycogen content of the normal uterine cervix was found to be fairly constant and apparently not regulated by steroid hormones. The low content of glycogen in malignant cervical tumours was confirmed by the present investigation. The present investigation also showed that this abnormality was not only characteristic of invasive carcinoma but also of carcinoma in situ. A particularly low glycogen content was found in tissue samples from patients with relapse. Concerning the enzyme involved in glycogen metabolism, a significantly high activity of glycogen synthetase was found in malignant cervical biopsies, while the activity of glycogen phosphorylase did not differ significantly when comparing normal to malignant tissue.