Open AccessSerum Alkaline Phosphatase in Pregnancy
Author(s) -
Romslo Inge,
Sagen Norvald,
Haram Kjell
Publication year - 1975
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016347509157106
Subject(s) - alkaline phosphatase , medicine , pregnancy , endocrinology , obstetrics , biochemistry , enzyme , chemistry , biology , genetics
Abstract. 312 paired, serial estimations of total, L‐phenylalanine‐sensitive and heat‐stable alkaline phos‐phatase (at two temperatures, 56°C and 65°C) were performed on sera from 31 pregnant healthy women from 18 weeks to term. Heat‐stable alkaline phosphatase, determined at 65°C, enriched the serum in a smooth exponential course throughout the second and third trimester, whereas the other enzymic activities investigated showed more irregular increments. There was a slight, but significant correlation between total alkaline phosphatase activity of the placenta and serum heat‐stable alkaline phosphatase at term, whereas there was no correlation between the weight of the child at birth and heat‐stable alkaline phosphatase in the serum of the mother. It is concluded that to test the feto‐maternal unit, determination of serum alkaline phosphatase should be performed at 65°C with due regard to appropriate sampling and experimental design.