Open AccessThe Radio‐Immunoassay of Follicle‐Stimulating Hormone (FSH) During Human Pregnancy: Serum Concentration and Response to Luteinizing Hormone Releasing Factor (LRF)
Author(s) -
Nakano Ryosuke,
Kayashima Fumiko,
Katayama Kazuaki,
Mizuno Tadayoshi,
Washio Motoo,
Tojo Shimpei
Publication year - 1974
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016347409162167
Subject(s) - luteinizing hormone , follicle stimulating hormone , endocrinology , medicine , hormone , pregnancy , immunoassay , anterior pituitary , antibody , biology , immunology , genetics
. Concentrations of follicle‐stimulating hormone (FSH) detectable by radio‐immunoassay and the FSH response to synthetic luteinizing hormone releasing factor (LRF) were measured in the sera of fourteen women during the first, the second and the third trimesters of pregnancy. Serum FSH was detectable, but relatively low in all the fourteen subjects throughout pregnancy. Moreover, exogenously administered synthetic LRF failed to stimulate serum FSH secretion from the anterior pituitary and there was no rise in serum FSH in all the fourteen pregnant women. Thus, it might be concluded that follicle‐stimulating activity of the hypophyseal gland is suppressed throughout human pregnancy by an unknown mechanism.