Open AccessHeterotransplantation of Human Foetal Testicular and Ovarian Tissue to the Mouse Mutant Nude
Author(s) -
Skakkebæk N. E.,
Jensen G.,
Povlsen C. O.,
Rygaard J.
Publication year - 1974
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016347409157196
Subject(s) - gonocyte , ovarian tissue , medicine , population , rete testis , sertoli cell , nude mouse , testicle , andrology , ovary , pathology , spermatogenesis , epididymis , sperm , environmental health , cancer
. Heterotransplantation of human foetal testicular and ovarian tissue from five human foetuses was performed on a total of 9 mice of the nude mutant. the grafts were inoculated subcutaneously and were accepted by 3 mice with testicular tissue and 2 mice with ovarian tissue. After 4 to 8 weeks the grafts were removed and prepared for light microscopy. in the testicular tissue both undifferentiated Sertoli cells and gonocytes were shown in the seminiferous tubules, and the gonocytes were present in 73 to 90 per cent of the tubular sections. in the ovarian tissue the structure was preserved and a mixed population of oogonia and oocytes was found.