Open AccessTrimethoprim‐Sulfonamide Combination Administered Orally and Intravaginally in the First Trimester of Pregnancy: Its Absorption into Serum and Transfer to Amniotic Fluid
Author(s) -
Ylikorkala O.,
Sjöstedt E.,
Järvinen P. A.,
Tikkanen R.,
Raines T.
Publication year - 1973
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016347309158319
Subject(s) - medicine , amniotic fluid , trimethoprim , pregnancy , absorption (acoustics) , sulfamethoxazole , sulfonamide , intravaginal administration , pharmacology , fetus , antibiotics , surgery , vagina , microbiology and biotechnology , chemistry , genetics , physics , acoustics , stereochemistry , biology
. The absorption of trimethoprim‐sulfonamide combination into serum and transfer to the amniotic fluid after oral and intravaginal administration was studied on 134 patients undergoing legal abortion. The combination given orally as a single dose was absorbed rapidly: the peak levels of both trimethoprim and sulfamethoxazole in serum were reached within 4 hours. In amniotic fluid, the peak level of trimethoprim appeared within 14 hours and that of sulfamethoxazole within 10 hours. After a single intravaginal application of cream, the absorption of trimethoprim into serum and transfer to the amniotic fluid was smaller although measurable amounts could be demonstrated. After repeated intravaginal application during several days no accumulation of trimethoprim in serum or amniotic fluid could be detected.