Open AccessFibrinolytic Activity of Veins During Treatment with Medroxyprogesterone Acetate
Author(s) -
Åstedt Birger
Publication year - 1972
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016347209156859
Subject(s) - medicine , medroxyprogesterone acetate , venous stasis , vein , coagulation , fibrinolysis , medroxyprogesterone , endocrinology , estrogen
Coagulation and fibrinolytic studies were performed on 18 postmenopausal women receiving medroxyprogesterone acetate S mg a day by mouth for one month. The fibrinolytic activity in the vessel wall was determined histochemically in vein biopsy specimens and in the blood after stimulation by venous stasis. In contrast with what is seen after oestrogen treatment the fibrinolytic activity in the vein vessel wall was unchanged. Neither were any changes found in the response of the fibrinolytic activity to venous stasis, or of the coagulation factors or components of the fibrinolytic system. The investigation thus produced no evidence of a thrombogenic effect of medroxyprogesterone acetate.