Open AccessThe Distribution of 125 I‐Marked Bovine Prolactin and Human Chorionic Gonadotrophin in Rats with Experimental Ovarian Tumours
Author(s) -
Carlsson Sten,
Kullander Stig,
Muller Edith R. A.
Publication year - 1972
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016347209154016
Subject(s) - prolactin , ovary , medicine , human chorionic gonadotropin , endocrinology , gonadotropin , bovine serum albumin , estrous cycle , oophorectomy , andrology , hormone , pathology , immunology , hysterectomy
The distribution and fate of 125 I‐labelled bovine prolactin, human chorionic gonadotropin and bovine serum albumin was studied and followed by serial gamma camera photographs, scintillation counting of blood and tissues, and autoradiography in normal pro‐oestrus rats, in oophorectomized rats and in rats with experimental ovarian tumours developed in intrasplenic ovarian grafts after bilateral oophorectomy. A high affinity for 125 I‐HCG was found both in ovarian tumours and in normal ovaries. An increased active tumour uptake of 125 I‐HCG was observed for 3 hours, which permitted tumour depicting with gamma‐camera technique. The 125 I‐prolactin uptake was more moderate both in ovaries and ovarian tumours. 125 I‐albumin showed no specific affinity. The possible application of these findings in diagnosis and therapy of human ovarian tumours is discussed.