Open AccessStudies on Fibrinolytic Inhibitors During Pregnancy
Author(s) -
Hedner Ulla,
Astedt Birger
Publication year - 1971
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016347109157294
Subject(s) - pregnancy , medicine , sephadex , endocrinology , macroglobulin , first trimester , gestation , enzyme , biochemistry , chemistry , biology , genetics
Individual fibrinolytic inhibitors (α 2 ‐macroglobulin, antiplasmin, plasminogen activation inhibitors), their relative values and the variation of such values as well as that of plasminogen were measured in 120 women during normal pregnancy (40 in each trimester). α 2 ‐macroglobulin and antiplasmin were increased throughout pregnancy. The inhibitors of plasminogen activation were determined by means of both a clot method and a caseinolytic method. The level remained largely unchanged during pregnancy. These findings were confirmed by the results obtained after gel filtration on Sephadex G‐200 of sera from 25 pregnant women. The level of plasminogen was found to be high during the whole of pregnancy. Our findings suggest that the reduced fibrinolytic activity during pregnancy is due to a decreased production and/or a defective release of plasminogen activators from the vessel walls.