Open AccessA Case of Hydatidiform Mole with Severe Preeclampsia and Severe Disturbances in Thyroid Function
Author(s) -
Kristoffersen K.,
Jørgensen F. Schønau
Publication year - 1970
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016347009158041
Subject(s) - medicine , preeclampsia , thyroid , pregnancy , thyroid function , thyroid function tests , endocrinology , proteinuria , triiodothyronine , kidney , genetics , biology
. A case is reported of a hydatidiform mole accompanied by a serious degree of toxaemia and severe disturbances in the function of the thyroid gland in a 20‐year‐old primigravida, who was admitted to the department in the 20th week of pregnancy. Clinically the patient showed severe toxaemia with gross oedema, congestion of the lungs, hypertension to approximately 200/ 130 mm Hg and proteinuria of 4.4 g/1000 ml, but no signs of thyrotoxicosis. The toxaemia disappeared within 14 days after treatment by evacuation, blood transfusion, albumin infusion, digitalization, diuretics and antihypertensive agents. Eight hours after removal of the mole an extremely high PBI (24.2 μg/100 ml) and a low serum cholesterol (97 mg/100 ml) were found. Both of these values returned to normal within the course of 14 days. Triiodothyronine uptake on Sephadex G 25 (T 3 test) was found to be 101% and fell simultaneously with the changes in the other values to 48%. I 131 uptake in the thyroid gland showed increased values 3 weeks after the operation but was normal again 5 weeks later. The values for the thyroid function tests which were found are compared with similar values reported in literature and it is concluded that the changes must be due to the usual effects on thyroid function of a normal pregnancy plus an extra factor, which must be produced by the molar tissue, and which must either be TSH or some other thyroid stimulator. It is recommended that in future TSH activity be determined in plasma and molar tissue in patients with hydatidiform mole and that various thyroid parameters be studied with regard to their possible diagnostic value in cases of hydatidiform mole.