Open AccessFibrinolytic Split Products in Serum and Urine in Pregnancy
Author(s) -
Hedner Ulla,
Åstedt Birger
Publication year - 1970
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016347009157269
Subject(s) - medicine , urine , pregnancy , urinary system , complication , fibrin , placenta , obstetrics , surgery , fetus , immunology , genetics , biology
Toxaemia and certain other complications of pregnancy appear to be accompanied by deposition of fibrin and microthrombosis in the kidneys, liver and placenta. When broken down these deposits and thrombi produce degradation products or split products. To assess the diagnostic value of determination of split products in serum and urine, 1 001 pregnant women were examined, on a single occasion during the latter part of pregnancy. 99 were found to have split products in the serum in a concentration of up to 3 mg/100 ml and 83.8% of them were found to have some complication, particularly toxaemia, hepatosis and urinary tract infections. No split products could be demonstrated in the urine in any of the women. Determination of fibrinolytic split products in serum is therefore recommended for early detection of complications and as an indicator of the effect of treatment of various complications during pregnancy.