Open AccessCytogenetic Investigations in Male Infertility
Author(s) -
Philip John,
Skakkebæk Niels E.,
Hammen Rich.,
Johnsen Svend G.,
Rebbe Heinrich
Publication year - 1970
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016347009157243
Subject(s) - chromatin , infertility , sex chromatin , male infertility , chromosome , medicine , genetics , andrology , y chromosome , chromatin remodeling , biology , physiology , gynecology , pregnancy , gene
. Sex‐chromatin and chromosomal investigations were carried out on 98 men, who were examined because of infertility. They all had severely impaired or totally absent fertility as evaluated by seminal analyses. Six were sex‐chromatin positive and had a 47, XXY chromosome complement. Furthermore one had a 47, XYY complement. This patient as well as the other 91 were chromatin‐negative. In another selection of hypogonadal men, both sex‐chromatin positive and sex‐chromatin negative patients with abnormal chromosome complements were found. It is therefore concluded that chromosomal abnormalities are important aetiological factors in male infertility. Chromosome analysis as well as sex‐chromatin analysis is thus necessary in the investigation of male infertility.