Open AccessRisk of impaired glucose tolerance in normal weight hirsute women during four years observation
Author(s) -
ANDRIES MAGDALENE,
GLINTBORG DORTE,
ANDERSEN MARIANNE
Publication year - 2010
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016341003801680
Subject(s) - medicine , hirsutism , quartile , body mass index , diabetes mellitus , impaired glucose tolerance , overweight , glucose tolerance test , endocrinology , type 2 diabetes , insulin resistance , polycystic ovary , confidence interval
Hirsutism is a common disorder affecting 5–20% of women in reproductive age. Only limited follow‐up data exist regarding the prognosis for glucose tolerance and metabolic risk factors in hirsutism. Sixty‐nine Caucasian hirsute women underwent a clinical examination and an oral glucose tolerance test (OGTT) during 1997–2002 (baseline) and during 2003–2004 (re‐evaluation). The observation period was (median; range) 4 (2–7) years. During re‐evaluation, body mass index (BMI) was 24.9 (22.4–29.0) kg/m 2 and total Ferriman‐Gallwey score was 10 (7–15) (median; 25–75% quartile). The women had unchanged BMI compared to baseline but increased fasting and 2 hour glucose levels. Impaired OGTT outcome during follow‐up was seen in 14/66 (21.2%) women, 5/66 (7.6%) developed diabetes. Women who took oral contraceptives had a significantly decreased area under the curve (AUC) for insulin during follow‐up, whereas AUC glucose levels increased. The present data supported a high risk of diabetes in only moderately overweight hirsute women.