Open AccessSerum tetranectin is a significant prognostic marker in ovarian cancer patients
Author(s) -
BEGUM FARAH DIBA,
HØGDALL ESTRID,
CHRISTENSEN IB JARLE,
KJAER SUSANNE KRÜGER,
BLAAKAER JAN,
CHRISTENSEN LISE,
HØGDALL CLAUS
Publication year - 2010
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016340903530936
Subject(s) - medicine , hazard ratio , confidence interval , proportional hazards model , stage (stratigraphy) , univariate analysis , ovarian cancer , oncology , multivariate analysis , survival analysis , epithelial ovarian cancer , cancer , gynecology , gastroenterology , paleontology , biology
Objective . To evaluate the prognostic value of preoperative serum tetranectin (TN) in Danish ovarian cancer (OvCa) patients. Design . Population‐based, multidisciplinary Danish case‐control study of OvCa. Participants . A total of 445 primary OvCa patients diagnosed at one of the gynecological departments in 18 regional hospitals around Denmark during the period 1994–1999. Methods . Serum levels of TN were evaluated preoperatively and tested for possible association with prognosis. Main outcome measures . Disease specific survival. Results . During the observation period (median 45.9 months, range 0.2–121) 278 OvCa‐related deaths were seen. Univariate analysis of TN and CA125 demonstrated a significant association with survival using the Cox proportional hazards model, when stratified for adjuvant treatment (TN: p < 0.0001, hazard ratio = 0.44; 95% confidence interval 0.33–0.60 and CA125: p < 0.0001, hazard ratio = 1.19; 95% confidence interval 1.11–1.27). Disease specific survival curves for patients with tumors in the early stages showed no significant association with survival, neither for TN ( p = 0.68) nor for CA125 ( p = 0.07). For the stage III group, a significant association with survival was found for TN ( p = 0.027), but not for CA125 ( p = 0.37). Multivariate Cox analysis identified TN, age, residual tumor, International Federation of Gynecology and Obstetrics stage and grade but not serum CA125 as independent prognostic variables. Conclusion . Preoperative serum TN is a useful prognostic indicator of advanced stage for patients with OvCa.