Open AccessYoung girls with malignant ovarian germ cell tumors can undergo normal menarche and menstruation after fertility‐preserving surgery and adjuvant chemotherapy
Author(s) -
YOO SEUNGCHUL,
KIM WOO YOUNG,
YOON JONGHYUCK,
CHANG SUKJOON,
CHANG KIHONG,
RYU HEESUG
Publication year - 2010
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016340903348383
Subject(s) - medicine , menarche , menstruation , germ cell tumors , chemotherapy , fertility , adjuvant , ovary , adjuvant chemotherapy , oncology , gynecology , germ cell , gynecologic surgical procedures , surgery , cancer , population , environmental health , biochemistry , chemistry , breast cancer , laparoscopy , gene
Objective. To evaluate the long‐term outcome and ovarian function in premenarchal and adolescent patients with malignant ovarian germ cell tumors after fertility‐preserving surgery and adjuvant chemotherapy. Design. Retrospective review of medical records. Setting. Ajou University Hospital, a tertiary care hospital in South Korea. Population. Forty‐five patients with malignant ovarian germ cell tumors. Methods. A retrospective analysis of patients with malignant ovarian germ cell tumors was conducted and a statistical analysis was performed. Main outcome measures. There were 9 premenarchal and 16 adolescent patients; the median ages at diagnosis were 7 and 18 years, respectively. All patients were treated with fertility‐preserving surgery. Seventeen of the patients received adjuvant chemotherapy with bleomycin, etoposide, and cisplatin (68.0%). There were no disease recurrences or deaths. Of the nine premenarchal patients, eight (88.9%) subsequently had normal menarche. Among the 16 adolescent patients, 15 (93.8%) resumed normal menstruation and 1 had premature ovarian failure. Conclusion. Premenarchal and adolescent patients with malignant ovarian germ cell tumors have excellent survival with fertility‐preserving surgery and adjuvant chemotherapy. The majority of these patients can have normal menarche and menstruation.