Open AccessTwo naturally occurring variants of the serotonin receptor gene HTR3C are associated with nausea in pregnancy
Author(s) -
GOECKE TAMME W.,
EKICI ARIF B.,
NIESLER BEATE,
LOEHBERG CHRISTIAN R.,
HAMMER CHRISTIAN,
RAPPOLD GUDRUN,
SCHANZE DENNY,
STRAUB VERICA,
ALTMANN HANSHARALD,
STRISSEL PAMELA,
STRICK REINER,
BECKMANN MATTHIAS W.,
FASCHING PETER A.
Publication year - 2010
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016340903322727
Subject(s) - nausea , pregnancy , single nucleotide polymorphism , medicine , vomiting , odds ratio , obstetrics , gynecology , gastroenterology , genotype , genetics , biology , gene
Objective. To assess the association between pregnancy‐associated symptoms and common single nucleotide polymorphisms (SNPs) in genes known to be involved in the pathogenesis of nausea and vomiting. Design. In a standardized, questionnaire‐based interview, women selected from a control cohort for association studies were asked retrospectively about nausea and vomiting during their first pregnancy. Population. A total of 593 women who had completed at least one pregnancy and for whom germline DNA was available were selected. Methods. Eight SNPs in the serotonin receptor genes HTR3A, HTR3B, HTR3C, HTR3D, HTR3E, and NK1R (TACR1) were tested using polymerase chain reaction. The occurrence of nausea and vomiting was correlated with the patients’ genotyping results and medical history parameters. Results. Both young age at first pregnancy and positive smoking status were significantly associated with vomiting and nausea during pregnancy. After adjustment for these two parameters, the two SNPs rs6806362 (odds ratio (OR) 1.38 per allele; 95% confidence interval (CI) 1.06–1.79; p = 0.017) and rs6807670 (OR 1.37; 95% CI 1.05–1.79 per allele; p = 0.023) were marginally associated with pregnancy‐related nausea. None of the other polymorphisms showed any association. Conclusion. Polymorphisms in the subunit gene HTR3C of the serotonin receptor may be involved in the pathogenesis of pregnancy‐associated nausea.