Open AccessSex ratio and pregnancy complications according to mode of conception in women with polycystic ovary syndrome
Author(s) -
VANKY ESZTER,
BACKE BJØRN,
CARLSEN SVEN M.
Publication year - 2009
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016340903294280
Subject(s) - polycystic ovary , medicine , offspring , pregnancy , obstetrics , gynecology , singleton , in vitro fertilisation , fertility , retrospective cohort study , spontaneous conception , population , obesity , insulin resistance , environmental health , biology , genetics
Objective. To investigate pregnancy complications and offspring sex ratio according to mode of conception in women with polycystic ovary syndrome (PCOS). Design. Retrospective, descriptive study. Setting. Tertiary, university hospital. Population. A total of 176 women with PCOS diagnosed according to the Rotterdam criteria. Methods. Women with PCOS who have participated in one or more clinical studies were invited to answer a questionnaire on the mode of conception, pregnancy complications, gestational length and offspring gender. A total of 139 women responded. Data were quality checked against hospital files. Main outcome measures. Fertility, mode of conception, offspring gender and pregnancy complications. Results. More than half (54%) of the singleton pregnancies were conceived spontaneously. More complications were seen in pregnancies achieved while using metformin than without ( p = 0.02). Compared to spontaneous conception, more boys than girls were born in singleton pregnancies after in vitro fertilization/intracytoplasmatic sperm injection treatment ( p = 0.004). Conclusions. In women with PCOS the mode of conception may influence both the rate of pregnancy complications and the offspring sex ratio.