Open AccessRole of skin dendritic and mast cells communications in triggering immune reactions
Author(s) -
N. V. Yaglova,
С. С. Обернихин,
V. V. Yaglov,
S.V. Nazimova
Publication year - 2021
Publication title -
kliničeskaâ i èksperimentalʹnaâ morfologiâ
Language(s) - English
Resource type - Journals
eISSN - 2686-6749
pISSN - 2226-5988
DOI - 10.31088/cem2021.10.1.5-10
Subject(s) - immune system , dendritic cell , mast cell , immunological synapse , antigen , immunology , biology , antigen presenting cell , microbiology and biotechnology , t cell , chemistry , t cell receptor
Skin represents a natural barrier and a site of contact with antigens. Skindemonstrates higher intensity of immune reactions compared to other organs, whichimplies the additional cell interactions. Dendritic cells are traditionally consideredas the main antigenpresenting cells of the skin, however, in recent years, some data onthe ability of another population, mast cells, to perform antigenpresenting functionshave appeared. The review presents novel data on the interaction of skin dendritic andmast cells, including formation of immune synapses, exchange of surface molecules, andtransfer of secretory material. The authors have developed and presented a new conceptfor the initiation and modulation of immune responses provided by the functionaldendritic cell–mast cell complex. Keywords: dendritic cells, mast cells, skin,immunological synapse, degranulatory synapse, immune response