Open AccessIntratumoral molecular genetic heterogeneity of glioblastomas
Author(s) -
П.В. Никитин,
Marina Ryzhova,
А А Потапов,
S.A. Galstyan,
D.S. Kim,
Т. Н. Панина,
S.V. Shugay,
Д.В. Старовойтов,
Е.А. Хохлова,
И.В. Зубова
Publication year - 2020
Publication title -
kliničeskaâ i èksperimentalʹnaâ morfologiâ
Language(s) - English
Resource type - Journals
eISSN - 2686-6749
pISSN - 2226-5988
DOI - 10.31088/cem2020.9.4.5-11
Subject(s) - genetic heterogeneity , glioblastoma , tumor heterogeneity , malignancy , biology , phenotype , cancer research , cell , tumor cells , molecular genetics , computational biology , cancer , genetics , gene
Intratumoral molecular genetic heterogeneity is not a less significant challenge in modern oncology than the intertumoral. The presence of cell populations within the same tumor, differing in their molecular properties, translated into phenotypic features of the cells, is one of the reasons for the inefficiency of many developments in the field of tumor therapy and the basis for the progression of malignant neoplasms. The issue under consideration is very relevant for glioblastoma (GBM) – being one of the deadliest human tumors; it practically does not lend itself to even promising experimental treatment methods. Therefore, this paper reviews intratumoral heterogeneity. The review in this aspect examines new experimental data, including those obtained using single-cell technologies, in particular, the key cell populations that make up the pool of tumor cells in glioblastoma, and their molecular metamodules, the presumptive role of some cell populations and their subpopulations in providing tumor malignancy properties. A promising groundwork for fundamentally new approaches to creating personalized diagnostic and therapeutic methods is indicated. Keywords: glioblastoma, intratumoral heterogeneity, glioblastoma genetics, single-cell sequencing