Open AccessPredictive and prognostic value of v-set and transmembrane domain-containing 1 expression in monocytes for coronary artery disease
Author(s) -
Xiaofei Wang,
Meng-Cheng Xu,
Chengyu Mao,
En-Zhou,
Qing He,
Xing Zhou Qu,
Yuqi Fan,
Changqian Wang,
Junfeng Zhang
Publication year - 2021
Publication title -
reviews in cardiovascular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.555
H-Index - 39
eISSN - 2153-8174
pISSN - 1530-6550
DOI - 10.31083/j.rcm2203110
Subject(s) - mace , medicine , cardiology , acute coronary syndrome , myocardial infarction , coronary artery disease , incidence (geometry) , asymptomatic , unstable angina , angina , percutaneous coronary intervention , physics , optics
The aim of this study was to investigate the correlation between v-set and transmembrane domain-containing 1 (VSTM1) expression and incidence of major adverse cardiac events (MACE) in patients with coronary heart disease (CHD). A total of 310 patients were divided into a non-acute coronary syndrome (non-ACS) group (containing the stable angina group, and the asymptomatic coronary artery diseaseand other patients group) and an ACS group (containing unstable angina and acute myocardial infarction patients). Monocytic VSTM1 expression levels (assessed via average fluorescence intensity derived from antibody binding to VSTM1) in each group were detected and analyzed. The cut-off value of monocytic VSTM1 expression to predict the onset of ACS and MACE was confirmed. VSTM1 expression in monocytes from the ACS group was lower than that of the non-ACS group. The incidence of MACEs in the high VSTM1-expression group was much less than that of those in the low VSTM1 expression group at the 1 year follow-up stage. VSTM1 expression had an independent-inversed association with increased incidence of MACE and ACS. VSTM1 expression in monocytes may help to predict the occurrence of ACS in patients with CHD, and moreover it may provide the means to evaluate MACE prognosis during CHD patient follow-up.