The Chinese Herb Codonopsis pilosula Isolate Isorhapontigenin protects against oxidative stress injury by inhibiting the activation of PI3K/Akt signaling pathway | Zendy

Youquan Gu | Zendy; Tianhong Wang | Zendy; Jun Chen | Zendy; Zhe Zhou | Zendy; Ying Wang | Zendy; Jiangjun Chen | Zendy; Ning Liu | Zendy; Zhenxiu Jiang | Zendy

Open Access

The Chinese Herb Codonopsis pilosula Isolate Isorhapontigenin protects against oxidative stress injury by inhibiting the activation of PI3K/Akt signaling pathway

Author(s) -

Youquan Gu,

Tianhong Wang,

Jun Chen,

Zhe Zhou,

Ying Wang,

Jiangjun Chen,

Ning Liu,

Zhenxiu Jiang

Publication year - 2020

Publication title -

journal of integrative neuroscience

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.336

H-Index - 33

eISSN - 1757-448X

pISSN - 0219-6352

DOI - 10.31083/j.jin.2020.02.1152

Subject(s) - pi3k/akt/mtor pathway , protein kinase b , phosphorylation , ly294002 , signal transduction , chemistry , oxidative stress , microbiology and biotechnology , pharmacology , biology , biochemistry

We investigated the effects of the Chinese herb Codonopsis pilosula isolate isorhapontigenin on antioxidant factor and the PI3K/Serine/Akt signaling pathway in Parkinson's disease. This research was, therefore, carried out to explore a possible protective mechanism of isorhamnetin in Parkinson's disease. The results support that isorhapontigenin could effectively inhibit isorhapontigenin restored myeloperoxidase + induced reduction of antioxidant levels. Also, 1-Methyl-4-phenylpyridine up-regulated the expression of phosphorylated-Akt, phosphorylated-PI3K, and phosphorylated mammalian target of rapamycin, while isorhapontigenin inhibited the expression of phosphorylated-Akt, phosphorylated-PI3K, and phosphorylated- mammalian target of rapamycin. Furthermore, LY294002 improved the antioxidant effect of isorhapontigenin in PC12 cells, and insulin-like growth factor 1 inhibited the antioxidant effect of isorhapontigenin in PC12 cells. Our results support the finding that isorhamnetin enhanced the antioxidant effect induced by 1-Methyl-4-phenylpyridine in PC12 cells by suppressing the activation of the PI3K/Akt signaling pathway.

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