Open AccessThe Effects of Parent Ages on Birth Defects
Author(s) -
James A. Thompson
Publication year - 2020
Publication title -
acta scientific paediatrics
Language(s) - English
Resource type - Journals
ISSN - 2581-883X
DOI - 10.31080/aspe.2020.03.0312
Subject(s) - gastroschisis , medicine , hypospadias , advanced maternal age , paternal age , confounding , demography , pediatrics , obstetrics , pregnancy , fetus , surgery , genetics , sociology , offspring , biology
Men and women, in the United States, are having children at considerably older ages. This changing demographic has been associated with multiple neonatal adverse birth outcomes that are currently considered to constitute a major public health crisis. The objective of this study was to evaluate the risk of parent age on birth defects and to provide results that can serve as a starting point for more specific mediation modeling. The modeling estimated the effects of parent age on birth defects controlling for confounding between maternal and paternal age and separated the mediating effect of chromosomal disorders, including Down syndrome.