Open AccessInnate receptors and IL-17 in the immune response against human pathogenic fungi
Author(s) -
María Soledad Miró,
Cecilia Vigezzi,
Eduardo Rodrı́guez,
Paula Alejandra Icely,
Juan Pablo Caeiro,
Fernando Riera,
Diana T. Masih,
Claudia Elena Sotomayor
Publication year - 2018
Publication title -
revista de la facultad de ciencias médicas de córdoba
Language(s) - English
Resource type - Journals
eISSN - 1853-0605
pISSN - 0014-6722
DOI - 10.31053/1853.0605.v73.n3.13353
Subject(s) - innate immune system , immune system , immunology , receptor , biology , microbiology and biotechnology , genetics
In recent years, the rise of human fungal infections has been associated to lack of early diagnosis, uneffective antifungal therapies and vaccines. Disturbance in immune homeostasis, which can be caused by medical interventions and immunosuppression induced by disease, are well known as risk factors for these pathologies. Cells of the innate immune system are equipped with surface and cytoplasmic receptors for recognition of microorganisms called pattern recognition receptors (PRRs). PRRs recognize specific pathogen-associated molecular patterns (PAMPs) that are crucial for the activation and killing of pathogenic fungi by immune system. This review will outline the PRRs and cells required for effective antifungal immunity, with a special focus on the major antifungal cytokine IL-17. Finally, naturally occurring human mutations involved in the increased susceptibility to fungal infections are also discussed