Open AccessInvestigation on Anti-Ulcer Activity of Momordica dioica Fruits in Wistar Rat
Author(s) -
Ashish Kumar,
Anubhav Dubey,
Raghuvendra Singh
Publication year - 2022
Publication title -
international journal for research in applied sciences and biotechnology
Language(s) - English
Resource type - Journals
ISSN - 2349-8889
DOI - 10.31033/ijrasb.9.1.12
Subject(s) - ulcer index , momordica , pylorus , chemistry , traditional medicine , ranitidine , distilled water , pharmacology , medicine , biochemistry , stomach , gastric mucosa , chromatography
To present study was carried out to investigate antiulcer activity of Ethanolic extract of Momordica dioica fruits in pylorus ligatated and Cold stress induced ulceration in the wistar rats. Pylorus ligation induced ulcer is one of the most widely used methods for studying the effect of drug on gastric secretion. Effect of distilled water in pylorus ligation has caused the accumulation of gastric sectretion and decreased the pH. Ranitidine and Ethanolic extracts of Momordica dioica significantly decreased the gastric volume, total acidity, free acidity, ulcer score, number of ulcer and ulcer index and raise the pH (shown in graph. 1, 2, 3, 4, 5, 6,).Similar studies support our results. Ethanolic extract of Momordica dioica at a dose of (400mg/kg. p.o) showed signicant inhibition of ulcerative lesion by 46.33% and 54.66%, respectively, as compared to the control value The Ethanol extract of Momordica dioica fruits possess significant antiulcer properties in a dose dependent manner.