BASES FOR METHODOLOGICAL APPROACHES TO FORECASTING OF PATHOGENESIS PROCESSES IN THE TREMATODE BODY AFTER ANIMAL CHEMOTHERAPY

The prospect of effective deworming is associated with the study of the mechanism of action of anthelmintics on helminths, its organs and tissues. The long-term use of methodological approaches using histological, histochemical and morphometric methods for studying organs and tissues of different types of trematodes (fascioli, euritrem, opisthorchia, dicrocelia, paramphistoma, etc.) after the anthelmintics action is effective, since it allows you to establish the mechanism and drug action on helminths. Using these methods, morphophysiological shifts were identified in the organs and tissues of trematodes, the degree of which corresponded proportionally to the dose of the applied anthelmintic on the one hand, and was determined by the chemical structure of the drug itself and the duration of its exposure, on the other. The importance of the trematodocidal effect of anthelmintics is associated with the ovicidal effect and the blocking of the trematode reproduction in which the process of egg formation is disturbed. The egg pathology covers not only the destruction of the structure of their contents at the cellular level, but is also associated with the destruction of their genome. The cessation of the release of invasive material or the release of degenerative eggs into the environment after deworming contributes to the ecologic sterilization of the environment, and its sanitation.