Open AccessDEVELOPMENT OF APPROACHES TO BIOTECHNOLOGICAL OBTAINING VACCINES FOR PREVENTION OF TISSUE HELMINTOSIS IN LIVE-STOCK ANIMALS
Author(s) -
M. N. Karagiaur,
A. V. Uspensky,
V. E. Abramov,
И. А. Архипов,
С. В. Абрамов,
A. V. Balyshev
Publication year - 2020
Publication title -
theory and practice of parasitic disease control
Language(s) - English
DOI - 10.31016/978-5-9902341-5-4.2020.21.123-127
Subject(s) - animal husbandry , pichia pastoris , microbiology and biotechnology , recombinant dna , livestock , agriculture , animal health , biology , business , veterinary medicine , medicine , ecology , biochemistry , gene
Tissue helminthiases, in particular, cystic echinococcosis and hydatidosis, coenurosis, trichinosis, etc. are a serious problem in places of intensive development of animal husbandry and agricultural production in many countries of the world. The existing system for the prevention of larval cestodoses is based on the implementation of veterinary-sanitary, therapeutic and organizational-economic measures. However, the level of livestock farming, especially in the individual sector, does not allow them to be fully implemented. In this regard, the development and implementation of protective drugs based on recombinant proteins is gaining important veterinary and health care value. For this purpose, in this work, a brief analysis of the prospects for the creation of antiparasitic vaccines using the expression system of recombinant proteins based on the yeast Pichia pastoris, allowing modification of expressed proteins and their secretion, was given. This approach provides the sufficient amount of relatively inexpensive recombinant protein.